Author

Piper Heine

University of WashingtonORCID 0009-0000-2220-8580Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. N. MurrayiD· 2 shared David A. BakeriD· 2 shared Lauren P. CarteriD· 2 shared Stacey GerbeniD· 2 shared Agnidipta GhoshiD· 1 shared Aleigha R. LawlessiD· 1 shared Alfredo Quijano‐RubioiD· 1 shared Andrew P. HinckiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

A. N. MurrayORCID

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2 papers

Recent·Most cited

BiochemistryScience ImmunologyPeer-reviewedSep 26, 2025

Potent antitumor activity of a designed interleukin-21 mimic

Jung-Ho Chun, Birkley S. Lim, Suyasha Roy…·David A. Baker

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.

20 citationstop 2%

humanmouse

𝕏 PostBluesky

BiochemistrybioRxivPreprintMay 1, 2024

Design of High Affinity Binders to Convex Protein Target Sites

David A. Baker, Wei Yang, Derrick R. Hicks…·Andrew P. Hinck

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

11 citations

protein structuredeep learning

𝕏 PostBluesky