Birkley S. Lim

This study identifies an IL-34-IGF-1 axis between macrophages and KRAS-mutant lung tumor cells that promotes tumor progression and poor survival.

This study develops pMHC-targeted retroviruses for in vivo gene delivery to tumor-specific T cells, enhancing their expansion and anti-tumor activity in mouse models.

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.