Jung-Ho Chun

This study designs protease-activatable cytokine prodrugs to reduce toxicity while maintaining antitumor efficacy in tumor models.

The paper designs novel cytokines by fusing computationally generated receptor-binding domains, identifying several that activate signaling pathways and have specific biological effects.

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.

This paper presents a computational strategy to design bifaceted protein nanomaterials with two distinct sides, enabling anisotropic functionalization and controlled structural variation.