Author

Leon-Phillip Szepanowski

Düsseldorf University HospitalORCID 0009-0000-2455-5957Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

James AdjayeiD· 3 shared Wasco WruckiD· 3 shared Abida Islam Pranty-Weßelmann· 1 shared Akua Afriyie KarikariiD· 1 shared Alessia LofranoiD· 1 shared Andrea RossiiD· 1 shared Christiane LoerchiD· 1 shared Ellen FritscheiD· 1 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

James AdjayeORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintDec 16, 2024

Investigating BPDE-induced embryonic toxicity employing hiPSC-based models

Vanessa Cristina Meira de Amorim, Leon-Phillip Szepanowski, Alessia Lofrano…·James Adjaye

This study examines BPDE toxicity in hiPSCs and NPCs, revealing hiPSCs are more sensitive to BPDE with enhanced p53-mediated DNA damage response, and NBS patient cells show reduced apoptosis.

1 citation

humanbulk RNA-seq

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NeuroscienceScientific ReportsPeer-reviewedOct 23, 2024

Hemozoin induces Malaria via activation of DNA damage, p38 MAPK and Neurodegenerative Pathways in Human iPSC-derived Neuronal Model of Cerebral Malaria

Abida Islam Pranty-Weßelmann, Leon-Phillip Szepanowski, Wasco Wruck…·James Adjaye

This study uses human iPSC-derived neuronal cultures exposed to hemozoin to show activation of DNA damage, p38 MAPK, and neurodegenerative pathways similar to cerebral malaria.

10 citations

humanbulk RNA-seq

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NeuroscienceCellsPeer-reviewedMar 28, 2024

Cockayne syndrome patient iPSC-derived brain organoids and neurospheres show early transcriptional dysregulation of biological processes associated with brain development and metabolism.

Leon-Phillip Szepanowski, Wasco Wruck, Julia Kapr…·James Adjaye

13 citations

humanbulk RNA-seq

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