Andrea Rossi

This study edits mtDNA variants in human iPSCs to show that heteroplasmic complex I variants impair neuronal commitment.

This study uses patient-derived iPSCs to model a MIC13 variant causing mitochondrial liver disease, revealing metabolic defects and early fibrosis through multi-omics analysis.

StabCell integrates clustering and marker detection in scRNA-seq to improve robustness and reduce false positives by assessing stability across subsampled data.

CleanFinder is a scalable framework for analyzing genome editing outcomes, enabling detailed genotyping and comparison across diverse edit types and contexts.

The paper develops a curated marker framework to identify early human developmental states and introduces a web tool for automated fate classification.

This study identifies fard-1 and dhs-25 as regulators of ferroptosis-driven aging in C. elegans by linking redox imbalance to oxidative stress and lifespan reduction.

This study uses NBS patient-derived cerebral organoids to show that impaired p53-mediated DNA damage response contributes to microcephaly by causing neuronal apoptosis and disrupted neurogenesis.

Duesselpore provides a local web server for analyzing Oxford Nanopore and NGS data, offering differential expression and downstream analyses without requiring bioinformatic expertise.

The paper introduces MAGECS, a fast and cost-effective method to select genome-edited cells using magnetic sorting of surface antigens in Cas9-positive cells.

The paper shows that mutant mRNA degradation triggers transcriptional adaptation in zebrafish and mouse, leading to upregulation of related genes.