Anisha S Menon

This study identifies RARA and RARG as cooperative regulators of axon regeneration in the CNS and PNS by reactivating developmental growth programs through combinatorial transcriptional control.

This study shows that three-dimensional genome organization in adult neurons encodes regenerative potential, with injury partially reversing this structure to re-engage developmental gene programs.

The paper shows PATZ1 promotes chromatin accessibility in injured neurons by remodeling nucleosomes at enhancers, facilitating axon regeneration.

DeNAT is a deep-learning tool that automatically measures neurite outgrowth in injury models with high accuracy and reduced variability compared to manual methods.

This study identifies NR2F1 and NR2F6 as nuclear receptor transcription factors that promote axon regeneration in the corticospinal tract through chromatin remodeling, enhancer redeployment, and translational reprogramming.

This study maps chromatin accessibility changes in mouse forebrain development and shows that PATZ1 can reverse epigenetic restrictions in adult neurons to enhance axon regeneration after injury.