Manojkumar Kumaran

KiMA provides an open-source tool for analyzing rodent gait and kinematics, integrating pose estimation with automated parameter calculation and visualization.

This study identifies RARA and RARG as cooperative regulators of axon regeneration in the CNS and PNS by reactivating developmental growth programs through combinatorial transcriptional control.

This study shows that three-dimensional genome organization in adult neurons encodes regenerative potential, with injury partially reversing this structure to re-engage developmental gene programs.

The paper shows PATZ1 promotes chromatin accessibility in injured neurons by remodeling nucleosomes at enhancers, facilitating axon regeneration.

This paper identifies a small molecule DM04 that mimics retinoic acid's effects on axon growth and motor recovery after spinal cord injury, acting through a non-canonical mechanism.

DeNAT is a deep-learning tool that automatically measures neurite outgrowth in injury models with high accuracy and reduced variability compared to manual methods.

This study identifies NR2F1 and NR2F6 as nuclear receptor transcription factors that promote axon regeneration in the corticospinal tract through chromatin remodeling, enhancer redeployment, and translational reprogramming.

This study maps chromatin accessibility changes in mouse forebrain development and shows that PATZ1 can reverse epigenetic restrictions in adult neurons to enhance axon regeneration after injury.

This study profiles the transcriptional response of supraspinal cell types to spinal injury in mice, finding that CST neurons respond more strongly to injuries closer to the brain than to distant spinal injuries.

The paper uses whole exome sequencing to identify pathogenic variants in a South Indian family with Primary Open Angle Glaucoma, finding variants in RPGRIP1 and ARHGEF40 that co-segregate with the disease.

This study evaluates 20 variant calling pipelines using WES data and simulated datasets to identify the best combinations for detecting SNVs and InDels.