A CAMKK2-UBR4-19S Proteasome Axis Regulates Chondrocyte Proteostasis and SOX9 Stability
Xinchun Ding, Yong Li, Kasi Hansen, Amber L. Mosley, Elizabeth Shinmay Yeh, Emma H. Doud, Uma Sankar
This study identifies CaMKK2 as a dual-function regulator of chondrocyte proteostasis by scaffolding the UPS-Ubr4-19S proteasome complex and enhancing proteasome activity through Psmc5 phosphorylation.
bioRxiv · May 12, 2026 · PreprintCell Biology