Cell BiologybioRxivPreprint
A CAMKK2-UBR4-19S Proteasome Axis Regulates Chondrocyte Proteostasis and SOX9 Stability
Xinchun Ding, Yong Li, Kasi Hansen…·Uma Sankar
This study identifies CaMKK2 as a dual-function regulator of chondrocyte proteostasis by scaffolding the UPS-Ubr4-19S proteasome complex and enhancing proteasome activity through Psmc5 phosphorylation.