Author

Uma Sankar

Indiana University IndianapolisORCID 0000-0002-9406-5686Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Adrianna N. Masterson· 1 shared Alexander G. RoblingiD· 1 shared Amber L. MosleyiD· 1 shared Andrei Bonteanu· 1 shared Christian S. WrightiD· 1 shared Danielle WuiD· 1 shared Elizabeth Shinmay YehiD· 1 shared Emma H. DoudiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Adrianna N. Masterson

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2 papers

Recent·Most cited

A CAMKK2-UBR4-19S Proteasome Axis Regulates Chondrocyte Proteostasis and SOX9 Stability

Xinchun Ding, Yong Li, Kasi Hansen, Amber L. Mosley, Elizabeth Shinmay Yeh, Emma H. Doud, Uma Sankar

This study identifies CaMKK2 as a dual-function regulator of chondrocyte proteostasis by scaffolding the UPS-Ubr4-19S proteasome complex and enhancing proteasome activity through Psmc5 phosphorylation.

bioRxiv · May 12, 2026 · PreprintCell Biology

Gabapentin Disrupts Binding of Perlecan to the α2δ1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation

Perla Citlali Reyes Fernandez, Christian S. Wright, Adrianna N. Masterson, Xin Yi, Tristen V. Tellman, Andrei Bonteanu, Katie Rust, Megan L. Noonan, Kenneth E. White, Karl J. Lewis, Uma Sankar, Julia M. Hum, Gregory Jaye Bix, Danielle Wu, Alexander G. Robling, , William R. Thompson

This study identifies a novel mechanosensory complex in osteocytes involving perlecan and α2δ1 subunit, showing that gabapentin disrupts their interaction and impairs bone mechanosensation.

Biomolecules · Dec 12, 2022Peer-reviewedMolecular Biology