Author

Xinyu Shi

Huazhong Agricultural UniversityORCID 0009-0000-5071-7905Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Approach:experimental assay· 1

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Dingqi LiuiD· 1 shared Jin HeiD· 1 shared Na TianiD· 1 shared Qingmin Ruan· 1 shared Xun WangiD· 1 shared Yuyang NiiD· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperSynthetic Biology

Dingqi LiuORCID

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1 paper

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Synthetic BiologybioRxivPreprintJun 20, 2026

Establishing a Retron-Based Cytosine Base Editor for Targeted Hypermutation in Escherichia coli

Xinyu Shi, Yuyang Ni, Na Tian…·Xun Wang

This paper develops a retron-based cytosine base editor (RCBE) that enables both C to T and G to A conversions in Escherichia coli, achieving a mutation rate of up to 0.2% in GC-rich regions.

DOI 10.64898/2026.06.18.733067

E. coliexperimental assay

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