Jin He

This paper develops a retron-based cytosine base editor (RCBE) that enables both C to T and G to A conversions in Escherichia coli, achieving a mutation rate of up to 0.2% in GC-rich regions.

This study uses pan-genome and multi-omics analyses to investigate the genomic basis of mycoheterotrophy in Gastrodia elata, revealing gene loss, regulatory co-option, and specialized nutrient acquisition mechanisms.

The paper identifies a regulatory circuit in mycobacteria that fine-tunes KatG expression to balance iron conservation and antioxidant defense under varying environmental conditions.

The paper identifies hyper-thermostable peptidoglycan hydrolases from bacterial proteomes using lysin-derived antimicrobial peptide screening and shows their potent bactericidal activity.

This study improves retron-based gene editing efficiency by reducing competition between msDNA and genomic DNA, achieving 100% editing efficiency.

The paper identifies Rho-dependent termination sites in vivo using synthetic sRNA by leveraging dsRNA cleavage and 3'-end stabilization.

The paper evaluates 25 theophylline riboswitches for gene repression in bacteria, finds limited effectiveness, and designs a more potent dual riboswitch system for efficient gene regulation.