Ming Lu

This study determines the Cryo-EM structure of the PHB complex and shows it organizes m-AAA proteases in mitochondrial microdomains to regulate proteolytic homeostasis.

DigitalBrain integrates and organizes human brain transcriptomic data across scales, revealing hierarchical organization and age-related gene reorganization.

This study determines the cryo-EM structure of the flotillin complex, revealing its role in membrane microdomain organization and phosphorylation-regulated assembly.

This study identifies CALHM2 as an ATP-regulated mitochondrial channel, showing it affects ATP levels and mTOR pathway activity, with implications for aging and disease.