Nathan O’Connor

This paper introduces a new optical framework and imaging devices that enable scalable, high-resolution, multi-immersion light-sheet microscopy for biological samples.

The paper investigates how engrams encode negative-hedonic valence related to alcohol withdrawal in rats, linking these engrams to compulsive alcohol seeking and relapse vulnerability.

The paper introduces ClearScope, a fully integrated light sheet theta microscope for sub-cellular resolution imaging of large specimens without lateral size constraints, demonstrating its use on mouse and human brain samples.

The paper compares topographic precision of ipsilateral and contralateral cortical projections in frontal, motor, and somatosensory areas of mice, finding stronger contralateral projections in frontal regions.

NeuroInfo automatically registers experimental mouse brain sections with a 3D atlas to accurately identify brain regions, improving navigation and reducing observer error.