Raju Tomer

Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy

This paper introduces a new optical framework and imaging devices that enable scalable, high-resolution, multi-immersion light-sheet microscopy for biological samples.

In vitro reconstitution of hippocampal cell assemblies

This study demonstrates that dissociated hippocampal cells can self-organize into network dynamics similar to in vivo cognitive cell assemblies, showing resilience and response to perturbations.

Squidiff: Predicting cellular development and responses to perturbations using a diffusion model

Squidiff predicts transcriptomic changes across cell types in response to environmental stimuli using a diffusion model, enabling in silico screening for drug discovery and precision medicine.

Multi-immersion Oblique Plane Microscope (miOPM): A reconfigurable platform for high-resolution Light-Sheet Fluorescence Microscopy.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia

This study identifies delayed cortical neuron development in 22q11.2DS-associated schizophrenia using brain organoids and single-cell RNA sequencing.

Capillary connections between sensory circumventricular organs and adjacent parenchyma enable local volume transmission

The paper identifies portal neurovascular connections between sensory circumventricular organs and adjacent brain tissue, enabling direct diffusible signaling.

Scalable projected Light Sheet Microscopy for high-resolution imaging of living and cleared samples

This paper introduces a cost-effective, scalable light sheet microscopy framework for high-resolution imaging of living and cleared samples, demonstrating its application on various biological samples.

ClearScope: a fully integrated light sheet theta microscope for sub-cellular resolution imaging without lateral size constraints

The paper introduces ClearScope, a fully integrated light sheet theta microscope for sub-cellular resolution imaging of large specimens without lateral size constraints, demonstrating its use on mouse and human brain samples.

Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system

This study uses whole-brain mapping to show that chronic ketamine exposure reduces dopamine neurons in midbrain regions but increases them in the hypothalamus, with divergent effects on brain connectivity.

Cortical Overgrowth in a Preclinical Forebrain Organoid Model of CNTNAP2-Associated Autism Spectrum Disorder

This study uses patient-derived forebrain organoids to investigate the effects of a CNTNAP2 mutation on cortical development, finding increased cell proliferation and differential gene expression associated with ASD.

Light Sheet Theta Microscopy for High-resolution Quantitative Imaging of Large Biological Systems

This paper introduces Light Sheet Theta Microscopy (LSTM) for high-resolution quantitative imaging of large biological systems, showing it achieves superior uniform resolution compared to traditional Light Sheet Microscopy.