Samoa Prieto-Diez

This study shows that eIF5A facilitates efficient translation of high codon-optimal chaperones under heat stress, enhancing proteostasis and heat resistance in yeast.

The paper identifies eIF5A as an indispensable protein in eukaryotic cells, showing that its duplicated paralogous genes act as a backup system to rescue mutations in the essential copy.

This study shows eIF5A coordinates gene expression by repressing transcription of its target genes in the nucleus while promoting their translation in the cytoplasm.