Paula M. Alepuz

This study shows that eIF5A facilitates efficient translation of high codon-optimal chaperones under heat stress, enhancing proteostasis and heat resistance in yeast.

The paper identifies eIF5A as an indispensable protein in eukaryotic cells, showing that its duplicated paralogous genes act as a backup system to rescue mutations in the essential copy.

This study shows eIF5A coordinates gene expression by repressing transcription of its target genes in the nucleus while promoting their translation in the cytoplasm.

This study shows that hypusinated eIF5A is essential for collagen translation, with depletion leading to reduced collagen levels and ER stress in mouse fibroblasts and human hepatic stellate cells.

This study investigates how Xrn1 affects transcription elongation in yeast by analyzing RNA polymerase II profiles and chromatin structure.