ImmunologyNaturePeer-reviewed
In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma
Nelson H. Knudsen, Giulia Escobar, Felix Korell…·Marcela Valderrama Maus
The paper uses in vivo CRISPR screens to identify genes affecting CAR T cell persistence and function in multiple myeloma, finding CDKN1B as a key regulator of late-stage CAR T cell fitness.
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