Author

Alexánder Rojas

Broad InstituteORCID 0000-0002-0110-929XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Kathleen B. YatesiD· 2 shared Nelson H. KnudseniD· 2 shared Robert T. MangusoiD· 2 shared Alexander ArmstrongiD· 1 shared Amanda A. BouffardiD· 1 shared Andrew Y. ChengiD· 1 shared Audrey J. MuscatoiD· 1 shared Celeste Nobrega· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

Kathleen B. YatesORCID

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2 papers

Recent·Most cited

In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma

Nelson H. Knudsen, Giulia Escobar, Felix Korell, Tamina Kienka, Celeste Nobrega, Seth Anderson, Andrew Y. Cheng, Maria Zschummel, Alexander Armstrong, Amanda A. Bouffard, Michael C. Kann, Sadie Goncalves, Hans W. Pope, Mitra Pezeshki, Alexánder Rojas, , Marcela Valderrama Maus

The paper uses in vivo CRISPR screens to identify genes affecting CAR T cell persistence and function in multiple myeloma, finding CDKN1B as a key regulator of late-stage CAR T cell fitness.

Nature · Sep 24, 2025Peer-reviewedImmunology

In vivo generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance

Kepler S. Mears, Kyrellos E. Ibrahim, Peter M. Allen, Jordan M. Chinai, Omar I. Avila, Audrey J. Muscato, Sarah Kate Lane-Reticker, Alexánder Rojas, Nelson H. Knudsen, Chun‐Cheih Chao, Kathleen B. Yates, Robert T. Manguso

This study develops lentiviral vectors with improved specificity and reduced immune clearance for in vivo CAR T cell generation, showing efficacy in a preclinical model.

bioRxiv · Apr 23, 2025 · PreprintBioengineering