Author

Amanda A. Bouffard

Harvard UniversityORCID 0009-0003-1501-4384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Marcela Valderrama MausiD· 2 shared Sangwoo ParkiD· 2 shared Trisha R. BergeriD· 2 shared Adele MucciiD· 1 shared Alexander ArmstrongiD· 1 shared Alexánder RojasiD· 1 shared Alexandra N. WolffiD· 1 shared Andrew Y. ChengiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioengineering

Marcela Valderrama MausORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintSep 27, 2026

Engineering CAR-T cells to remodel the mucin-rich cancer cell glycocalyx

Sangwoo Park, Cassidy Ho, Alexandra N. Wolff…·Marcela Valderrama Maus

This study engineers CAR-T cells to secrete KLK5, a protease that remodels the mucin-rich glycocalyx, enhancing CAR-T cell function and tumor control in xenograft models.

DOI 10.64898/2026.09.25.754490

humanproteomics

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ImmunologyNaturePeer-reviewedSep 24, 2025

In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma

Nelson H. Knudsen, Giulia Escobar, Felix Korell…·Marcela Valderrama Maus

The paper uses in vivo CRISPR screens to identify genes affecting CAR T cell persistence and function in multiple myeloma, finding CDKN1B as a key regulator of late-stage CAR T cell fitness.

50 citationstop 1%

humangenetic perturbation / CRISPR

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