Debattama R. Sen

This study identifies sex-biased mechanisms of immune aging in males, showing lymph node contraction reduces naive CD8 T cell availability and compromises cancer antigen recognition, with potential therapeutic interventions.

This study identifies Dusp5 and Zfp219 as key regulators of age-related T cell dysfunction using CRISPR screens and shows their potential as therapeutic targets.

This study shows CD40 agonist therapy reduces tumor growth in antigen presentation-deficient tumors by reprogramming monocytes and requiring IFN-gamma and CD8+ T cells for efficacy.

This study identifies a novel CD8+ TIL subset that uses lymphotoxin and IFN pathways to kill cancer cells, linking LTB expression to clinical response in melanoma.

The paper uses in vivo CRISPR screens to identify genes affecting CAR T cell persistence and function in multiple myeloma, finding CDKN1B as a key regulator of late-stage CAR T cell fitness.

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.