BiochemistryNature Chemical BiologyPeer-reviewed
PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates
Zhenguang Zhao, Wenqing Xu, Ethan Yang Feng…·Christina M. Woo
The paper identifies PCMT1 as an enzyme that forms C-terminal cyclic imides on CRBN substrates, linking it to metabolic enzyme regulation and epileptic phenotypes.
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