LKB1 Spatially Regulates AMPK Activity Coordinate Cellular Oxidative Stress Response
Kasey Parks, Arnav Jhawar, Alexia Andrikopoulos, Declan M. Winters, Teagan S. Dean, Edmund D. Kapelczak, Tara A. TeSlaa, Mehdi Bouhaddou, Danielle L. Schmitt
This study shows that LKB1 spatially regulates AMPK activity in response to oxidative stress, affecting metabolic and gene expression changes, and identifies impaired LKB1-AMPK signaling in certain cancers.
bioRxiv · Nov 17, 2025 · PreprintBiochemistry