Tara A. TeSlaa

Flexibility of systemic one-carbon metabolism partially buffers dietary methyl donor deficiency

This study investigates how systemic one-carbon metabolism compensates for dietary methyl donor deficiency by inter-organ nutrient exchange.

Optical metabolic imaging of the tricarboxylic acid cycle

This paper introduces MATRIX-SRS, a method to image TCA cycle activity in live cells, revealing metabolic changes during epithelial-to-mesenchymal transition.

Illuminating spatial dynamics of glutamine metabolism with a sensitive genetically encoded biosensor

The paper develops a genetically encoded biosensor, iGlo, to study glutamine metabolism dynamics across organelles and cells, revealing temporal crosstalk between glucose and glutamine metabolism.

Single-Cell Metabolic Imaging Reveals Glycogen Driven-Adaptations in Endothelial Cells

This study uses SRS microscopy to show that endothelial cells store glycogen under diabetes-like stress, which helps them survive glucose starvation and may offer new therapeutic targets for diabetes-related endothelial dysfunction.

LKB1 Spatially Regulates AMPK Activity Coordinate Cellular Oxidative Stress Response

This study shows that LKB1 spatially regulates AMPK activity in response to oxidative stress, affecting metabolic and gene expression changes, and identifies impaired LKB1-AMPK signaling in certain cancers.

A Genetically Encoded Fluorescent Biosensor for Intracellular Measurement of Malonyl-CoA

This paper develops a genetically encoded fluorescent biosensor, Malibu, to measure intracellular malonyl-CoA dynamics in single cells, showing increased responses to fatty acid biosynthesis inhibitors.

Quantitative fluxomics of circulating metabolites

This study quantifies metabolic fluxes of circulating metabolites in mice using isotope tracing and mass spectrometry to identify major metabolic cycles and their tissue-specific contributions.