Edmund D. Kapelczak

This study investigates how systemic one-carbon metabolism compensates for dietary methyl donor deficiency by inter-organ nutrient exchange.

This paper introduces MATRIX-SRS, a method to image TCA cycle activity in live cells, revealing metabolic changes during epithelial-to-mesenchymal transition.

The paper develops a genetically encoded biosensor, iGlo, to study glutamine metabolism dynamics across organelles and cells, revealing temporal crosstalk between glucose and glutamine metabolism.

This study uses SRS microscopy to show that endothelial cells store glycogen under diabetes-like stress, which helps them survive glucose starvation and may offer new therapeutic targets for diabetes-related endothelial dysfunction.

This study shows that LKB1 spatially regulates AMPK activity in response to oxidative stress, affecting metabolic and gene expression changes, and identifies impaired LKB1-AMPK signaling in certain cancers.

This paper develops a genetically encoded fluorescent biosensor, Malibu, to measure intracellular malonyl-CoA dynamics in single cells, showing increased responses to fatty acid biosynthesis inhibitors.