Author

Garret Manquen

St. Jude Children's Research HospitalORCID 0009-0001-2131-1874Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Shengdar Q. TsaiiD· 2 shared Varun KattaiD· 2 shared Yichao LiiD· 2 shared Akshay SharmaiD· 1 shared Alicia Powers· 1 shared Binfan Chen· 1 shared Bony De KumariD· 1 shared Caihong QiuiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

Shengdar Q. TsaiORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintNov 13, 2025

Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome

Xiaona Lu, Ying Xie, Youmei Bao…·Jiangbing Zhou

This paper develops a non-viral genome-editing method called STEP-RNPs that effectively treats Angelman syndrome in mice and human neurons, showing functional genetic rescue without off-target effects.

1 citation

mousehuman

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GenomicsMolecular TherapyPeer-reviewedJul 30, 2024

Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34+ cell therapy to induce fetal hemoglobin for sickle cell disease

Varun Katta, Kiera O’Keefe, Yichao Li…·Shengdar Q. Tsai

This study develops a genome-edited autologous CD34+ cell therapy to induce fetal hemoglobin for sickle cell disease, showing efficient editing, therapeutic HbF levels, and no off-target effects.

18 citations

humanwhole-genome sequencing

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