Author

Joseph F. Hoff

University of BristolORCID 0009-0001-2367-8514Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Adrian John MulhollandiD· 2 shared Catherine L. TookeiD· 2 shared Christopher John SchofieldiD· 2 shared JAMES M. SPENCERiD· 2 shared Michael BeeriD· 2 shared Philip HinchliffeiD· 2 shared Andrew F. CadzowiD· 1 shared John M. ShawiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Adrian John MulhollandORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintApr 16, 2026

Acyl-enzyme dynamics, tautomerisation and hydration regulate turnover of carbapenem antibiotics by the OXA-48 β-lactamase

Joseph F. Hoff, Michael Beer, Philip Hinchliffe…·JAMES M. SPENCER

This study investigates how acyl-enzyme tautomerisation, dynamics, and hydration affect carbapenem antibiotic turnover by OXA-48 β-lactamase using X-ray crystallography and molecular dynamics simulations.

1 citation

mechanistic / dynamical model

𝕏 PostBluesky

BiochemistryRSC Medicinal ChemistryPeer-reviewedJan 1, 2025

Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

Joseph F. Hoff, Kirsty E. Goudar, Karina Calvopiña…·JAMES M. SPENCER

This paper compares the potency of nacubactam and avibactam against OXA-48-like β-lactamases, finding that nacubactam is less potent due to electrostatic repulsion with Arg214.

5 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky