Author

Shinn-Juh Lai

National Taiwan UniversityORCID 0009-0001-2759-2259Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Hsin-Hung David ChouiD· 2 shared Joshua Kevin Chang· 2 shared Syue-Ting Antony KuoiD· 2 shared Wei-Yi Shen· 2 shared Cheng-Wei Ni· 1 shared Chih-Chiang Chang· 1 shared Christine Hsu· 1 shared Clara Chang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSystems Biology

Hsin-Hung David ChouORCID

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2 papers

Recent·Most cited

Systems BiologyNature CommunicationsPeer-reviewedJul 17, 2026

Core elements play distinct roles in promoter birth and transcriptional regulation

Syue-Ting Antony Kuo, Wei-Yi Shen, Shinn-Juh Lai…·Hsin-Hung David Chou

The paper investigates the roles of core promoter elements -35 and -10 in Escherichia coli, showing -10 is essential for promoter evolution while -35 influences gene regulation through interactions with transcription factors.

DOI 10.1038/s41467-026-75686-2

E. coliDNA methylation

𝕏 PostBluesky

GenomicsNucleic Acids ResearchPeer-reviewedNov 13, 2025

Unraveling the start element and regulatory divergence of core promoters across the domain Bacteria

Syue-Ting Antony Kuo, Joshua Kevin Chang, Clara Chang…·Hsin-Hung David Chou

The paper identifies a conserved 3-bp promoter element and reveals regulatory divergence in bacterial promoters between Terrabacteria and Gracilicutes.

7 citationstop 5%

bacteria (other)experimental assay

𝕏 PostBluesky