Gist H. Farr

This study identifies proteasome factors as contributors to heart development and congenital heart defects using a systems genetics approach combining transcriptomics, PPI networks, and CRISPR screening in zebrafish.

The paper develops a machine learning classifier to identify mouse genes involved in cardiac development and prioritizes them for potential human congenital heart disease (CHD) causation.

This paper shows that wnt16 regulates spine and muscle morphogenesis in zebrafish through signals from notochord and dermomyotome, explaining its dual role in bone and muscle traits.

This study shows that Pbx factors are essential for embryonic fast-twitch muscle differentiation in both zebrafish and mice, with conserved gene regulation mechanisms.

The paper tests a human PBX3 variant in zebrafish to show it may modify congenital heart defect risk by enhancing cardiac morphogenesis defects.