Author

Jonathan Karlin

Thomas Jefferson UniversityORCID 0009-0001-4309-8875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Samantha M. BarnadaiD· 2 shared Steven B. McMahoniD· 2 shared Aida Giner de Gracia· 1 shared Chiara ScopaiD· 1 shared Cruz Morenilla‐PalaoiD· 1 shared Davide TrottiiD· 1 shared Eloı́sa HerreraiD· 1 shared Francis J. Waltrich· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Samantha M. BarnadaORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 17, 2026

Lung cancer-enriched p53 mutants occupy canonical p53 target genes without activating transcription, revealing a distinct loss-of-function behavior

Mason Tracewell, Hailey N. Shankle, Samantha M. Barnada…·Steven B. McMahon

The paper identifies lung cancer-specific p53 mutants that bind genomic sites but fail to activate transcription, revealing a novel loss-of-function mechanism in lung cancer.

DOI 10.64898/2026.02.14.705936

humanDNA methylation

𝕏 PostBluesky

Developmental BiologybioRxivPreprintApr 3, 2024

ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial to mesenchymal transition in cranial neural crest lineage commitment

Samantha M. Barnada, Aida Giner de Gracia, Cruz Morenilla‐Palao…·Marco Trizzino

The paper shows ARID1A-haploinsufficiency impairs EMT in CNCC specification by disrupting ARID1A-BAF binding at EMT enhancers, which affects ZIC2 occupancy and leads to aberrant neuronal gene activation.

2 citations

mousehuman

𝕏 PostBluesky