Steven B. McMahon

The paper identifies lung cancer-specific p53 mutants that bind genomic sites but fail to activate transcription, revealing a novel loss-of-function mechanism in lung cancer.

This study examines how PARP inhibitors affect transcriptional responses in prostate cancer patients of different racial backgrounds, finding race-based differences in PARP1 expression and distinct transcriptional programs for each inhibitor.

The paper shows ARID1A-haploinsufficiency impairs EMT in CNCC specification by disrupting ARID1A-BAF binding at EMT enhancers, which affects ZIC2 occupancy and leads to aberrant neuronal gene activation.