Author

Francis J. Waltrich

Thomas Jefferson University

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Developmental Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Aida Giner de Gracia· 1 shared Chiara ScopaiD· 1 shared Cruz Morenilla‐PalaoiD· 1 shared Davide TrottiiD· 1 shared Eloı́sa HerreraiD· 1 shared Gijs W.E. SanteniD· 1 shared Harald M. M. MikkersiD· 1 shared Jonathan KarliniD· 1 shared

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2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperDevelopmental Biology

Aida Giner de Gracia

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1 paper

Recent·Most cited

ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial to mesenchymal transition in cranial neural crest lineage commitment

Samantha M. Barnada, Aida Giner de Gracia, Cruz Morenilla‐Palao, María Teresa López-Cascales, Chiara Scopa, Francis J. Waltrich, Harald M. M. Mikkers, M.E. Cicardi, Jonathan Karlin, Davide Trotti, Kevin A. Peterson, Samantha A. Brugmann, Gijs W.E. Santen, Steven B. McMahon, Eloı́sa Herrera, Marco Trizzino

The paper shows ARID1A-haploinsufficiency impairs EMT in CNCC specification by disrupting ARID1A-BAF binding at EMT enhancers, which affects ZIC2 occupancy and leads to aberrant neuronal gene activation.

bioRxiv · Apr 3, 2024 · PreprintDevelopmental Biology