Author

Nicole Sanhueza

Universidad MayorORCID 0009-0001-5173-0471Unclaimed ORCID profile · follow to get notified of new preprints

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Neuroscience· 1

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Organism:Drosophila· 1 Approach:experimental assay· 1

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Felipe A. CourtiD· 1 shared Francisco Muñoz-CarvajaliD· 1 shared Mario SanhuezaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperNeuroscience

Felipe A. CourtORCID

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1 paper

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NeuroscienceeLifePeer-reviewedMar 26, 2026

Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila.

Francisco Muñoz-Carvajal, Nicole Sanhueza, Mario Sanhueza, Felipe A. Court

This study shows that age-dependent H3K9 trimethylation by dSetdb1 impairs UPRMT in Drosophila olfactory neurons, leading to neurodegeneration and loss of olfactory function, which can be reversed by dSetdb1 knockdown.

DOI 10.7554/elife.103118

Drosophilaexperimental assay

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