Felipe A. Court

The Neuroactive Potential of the Elderly Human Gut Microbiome is Associated with Mental Health Status

This study links the neuroactive potential of the elderly gut microbiome to mental health and cognition in older adults with cognitive complaints.

Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in Drosophila.

This study shows that age-dependent H3K9 trimethylation by dSetdb1 impairs UPRMT in Drosophila olfactory neurons, leading to neurodegeneration and loss of olfactory function, which can be reversed by dSetdb1 knockdown.

Applying the area fraction fractionator (AFF) probe for total volume estimations of somatic, dendritic and axonal domains of the nigrostriatal dopaminergic system in a murine model

The paper describes a protocol to estimate total volumes of nigrostriatal dopaminergic domains in mice using stereological methods and provides volume proportions for different cellular components.

Impact of cardiometabolic factors and blood beta-amyloid on the volume of white matter hyperintensities in dementia-free subjects with cognitive complaints

The paper examines the relationship between cardiometabolic factors, blood beta-amyloid, and white matter hyperintensities in dementia-free individuals with cognitive complaints, finding stronger associations with cardiometabolic markers.

Necroptosis inhibition counteracts neurodegeneration, memory decline and key hallmarks of aging, promoting brain rejuvenation.

This study shows that inhibiting necroptosis in aged mice reduces axonal degeneration, neuroinflammation, and memory decline, promoting brain rejuvenation.

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

This study shows that senescent Schwann cells, induced by aging and chronic denervation, impair axonal regeneration by reducing c-Jun expression and secreting inhibitory factors, and that eliminating these cells improves regeneration.

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates

This study identifies IGF2 as a disease modifier that reduces intracellular protein aggregates by promoting their extracellular disposal in Huntington's disease models.

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease

This study shows that necroptosis mediates axonal degeneration in Parkinson's disease, suggesting it as a targetable pathway.