Ryan Moreno

SARDINE unlocks EWAS summary statistics for large-scale epigenetic biomarker analysis

SARDINE uses EWAS summary statistics to estimate epigenetic clock-phenotype associations without individual-level data, revealing heterogeneity in biomarker associations with aging and diseases.

Long-read, whole-genome sequencing and chemotherapy response of two patient-derived organoids from a TP53- and KRAS-mutant ovarian carcinoma

This paper describes two patient-derived organoids from a TP53- and KRAS-mutant ovarian carcinoma, showing differential chemotherapy response and using long-read sequencing to characterize structural variants and methylation differences.

Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer cell lines and isogenic models

This study profiles 36 ovarian cancer cell lines to identify genetic and gene expression signatures associated with platinum response, revealing cell line sensitivity and resistance to cisplatin and carboplatin.