Jessica D. Lang

This paper describes two patient-derived organoids from a TP53- and KRAS-mutant ovarian carcinoma, showing differential chemotherapy response and using long-read sequencing to characterize structural variants and methylation differences.

This study identifies Polo-like kinase 1 (Plk1) as a regulator of mitotic transcription, showing its role in maintaining chromosomal accessibility and transcriptional activity during mitosis.

This study profiles 36 ovarian cancer cell lines to identify genetic and gene expression signatures associated with platinum response, revealing cell line sensitivity and resistance to cisplatin and carboplatin.

Bisbee detects differential splicing and identifies splice outliers with improved sensitivity and specificity using proteomics validated methods.