Author

Sophie E. Fountain

University of SheffieldORCID 0009-0001-6384-4476Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Approach:experimental assay· 1

Frequent Co-Authors

Mahmoud A. S. AbdelhamidiD· 2 shared Timothy D. CraggsiD· 2 shared David M. WilliamsiD· 1 shared Dilek GuneriiD· 1 shared Elisé P. Wright· 1 shared Yiliang DingiD· 1 shared Zara Campos Carrillo De Preciado· 1 shared Zoë A. E. WalleriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 23 mutual co-author links

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2 shared papersBiophysics

Mahmoud A. S. AbdelhamidORCID

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2 papers

Recent·Most cited

BiophysicsNucleic Acids ResearchPeer-reviewedSep 15, 2026

DNA damage induces long range changes to duplex structure - a non-protein start to damage detection?

Sophie E. Fountain, Mahmoud A. S. Abdelhamid, David M. Williams, Timothy D. Craggs

This study shows DNA damage alters duplex structure and dynamics, potentially signaling repair protein recruitment through changes in DNA flexibility.

DOI 10.1093/nar/gkag920

experimental assay

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BiophysicsbioRxivPreprintMar 2, 2026

RNA i-Motif Formation at Neutral pH

Zara Campos Carrillo De Preciado, Sophie E. Fountain, Elisé P. Wright…·Zoë A. E. Waller

This study investigates RNA i-motif stability at neutral pH, finding that while ensemble experiments show global unfolding, single-molecule experiments reveal a small fraction remains folded.

1 citation

biophysical modeling

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