Mahmoud A. S. Abdelhamid

This study shows DNA damage alters duplex structure and dynamics, potentially signaling repair protein recruitment through changes in DNA flexibility.

The paper investigates how the 2A protein interacts with the RNA genome of cardioviruses to activate ribosomal frameshifting through structural changes in the RNA.

This paper uses FCCS to quantify affinity, cooperativity, and kinetic stability in ternary protein complexes, showing cooperative stabilization of the HER2-trastuzumab-pertuzumab complex.

This study investigates RNA i-motif stability at neutral pH, finding that while ensemble experiments show global unfolding, single-molecule experiments reveal a small fraction remains folded.

This study investigates the conformational flexibility of kinesin-1 using biophysical methods, revealing its open structure without cargo and insights into autoinhibition.

This study investigates the conformational transitions of Rep helicase using single-molecule techniques, revealing two intermediate states influenced by salt concentration.