Qiandi Gao

The paper uses a protein language model to analyze the evolutionary history of bacterial aromatic polyketide ketosynthases and chain length factors, identifying a shared ancestral cluster and distinct evolutionary paths.

DeepAden predicts A-domain substrate specificities in NRPSs using a two-stage deep learning framework, achieving competitive performance and enabling the identification of novel NRP gene clusters.

This study identifies holomycin as a key factor in Yersinia ruckeri infection of rainbow trout at low temperatures, showing it remodels host microbiota and enhances biofilm formation.