Targeting HMGA1-driven leukemic transformation in myeloproliferative neoplasms with pacritinib
Can Hui Yang, Yajun Li, Kun Chen, Xuemei Tang, Qingyun Zhang, Wenjiao Qin, Yu Zeng, Jianfei Fu, Xiaotong Ma, Wenshu Zheng, Zhen Dong Huang, Wenhao Zhang, Gusheng Tang, Ming Guan, Zhiyuan Wu
This study identifies HMGA1 as a critical driver of MPN progression to sAML, showing it outperforms existing markers and is targeted by pacritinib to improve survival.
bioRxiv · Jun 1, 2025 · PreprintCancer Biology