Targeted-SMN insufficiency in Skeletal Muscle Stem Cells mediates non-cell autonomous loss of motor neurons at long term
Jordan Mecca, Julien Mignot, Marianne Gervais, Teoman Ozturk, Stéphanie Astord, Juliette Berthier, Stéphanie Bauché, Julien Messéant, Maria Grazia Biferi, Hélène Rouard, Martine Barkats, Frédéric Relaix, Nathalie Didier
This study shows that SMN insufficiency in muscle stem cells leads to long-term motor neuron loss through non-cell autonomous mechanisms in SMA.
Brain · Feb 5, 2026Peer-reviewedPathology