Athanassia Sotiropoulos

EYA1/EYA2 and EYA3/EYA4 act as stage-specific SIX cofactors in embryonic and adult regenerative skeletal myogenesis

This study investigates the role of EYA1/EYA2 and EYA3/EYA4 in skeletal myogenesis, showing that EYA3/EYA4 are critical for adult muscle regeneration while EYA1/EYA2 are essential for embryonic development.

Identification of a new population of myonuclei during skeletal muscle hypertrophy

The paper identifies a new population of myonuclei during skeletal muscle hypertrophy using snRNA-seq and RNAscope, showing distinct localization and gene expression profiles.

c-MAF transduces fast motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions

This study identifies c-MAF as a mediator of motoneuron activity in maintaining fast-glycolytic muscle fibers and neuromuscular junctions through chromatin accessibility changes and gene regulation.

SIX1-dependent myofiber typology and metabolism controls muscle hypertrophy

This study shows that SIX1 regulates muscle fiber hypertrophy by modulating metabolism and fiber type transitions in response to mechanical overload.

Transient hypoxia followed by progressive reoxygenation is required for efficient skeletal muscle repair through Rev-ERBalpha modulation

This study shows that transient hypoxia followed by reoxygenation is essential for skeletal muscle repair, mediated by Rev-ERBalpha regulation of myogenesis.