Chen Wang

The paper uses RIC-seq and integrates multi-omics data to classify transcription factors into two clusters based on RNA-RNA spatial interactions and their genomic and clinical features.

This study shows that high VISTA expression in cancer cells indicates a less malignant state and affects actin cytoskeleton, suggesting immune checkpoints may have non-immunological roles in cancer.

This study shows that cancer cell tumorigenicity and immunogenicity are inversely related to their differentiation status, with differentiation suppressing tumorigenicity and enhancing immunogenicity.

This study reveals the in-situ architecture of the mammalian pyruvate dehydrogenase complex using cryo-electron tomography, showing dynamic interactions and variable peripheral compositions.