Author
Broad InstituteORCID 0000-0001-5287-0284Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Sherif Gerges, Nikolaj Catois Straarup, Mohamed A. El-Brolosy…·Mark J. Daly
The paper integrates genetic, transcriptomic, and structural data to show that Ca2+ dysregulation via ATP2B2 missense variants contributes to neuropsychiatric disorders.
Ajay Nadig, Matthew Tegtmeyer, Ajinkya Patil…·Elise Robinson
The paper identifies chr22q as a regulatory hub where genetic risk for neuropsychiatric conditions is associated with coordinated gene expression downregulation in brain tissue.
Shengtao Yang, Dibyadeep Datta, Fenna M. Krienen…·Min Wang
This study shows that kynurenic acid (KYNA) and its enzyme KAT II expand in primate dlPFC, impairing cognitive functions by affecting NMDA and nic-7Rs, and suggests targeting KYNA as a therapeutic approach for neuroinflammatory disorders.
Emi Ling, James C. Nemesh, Melissa Goldman…·Steven A. McCarroll
The paper identifies a neuron-astrocyte gene expression program, SNAP, that declines in aging and schizophrenia, linking it to cognitive function and genetic risk factors.
Marty G. Yang, Emi Ling, Christopher J. Cowley…·Thomas Vierbuchen
The paper identifies sequence variants affecting enhancer function by analyzing TF binding and activity in hybrid mice fibroblasts.