Christopher D. Mullally

This study shows that endogenous APOBEC3B causes DNA damage and replication stress, making cancer cells sensitive to CHK1 inhibitors.

This paper introduces collapsing retroviruses (CRVs) to deliver viro-toxic cargoes like APOBEC3B by using recombination to restore gene integrity during transduction, achieving near 100% efficiency.

This paper reports the cryoEM structure of full-length APOBEC3B in complex with BORF2, revealing its domain organization and mechanism of viral neutralization and mutagenesis.

HAMMER is a luminescence-based assay that measures APOBEC3A-mediated RNA editing by detecting changes in luciferase activity ratios.

This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.

The paper shows that HTT CAG repeats expand in striatal neurons over time, leading to gene expression changes and neurodegeneration in Huntington disease.

The paper identifies a neuron-astrocyte gene expression program, SNAP, that declines in aging and schizophrenia, linking it to cognitive function and genetic risk factors.

This study identifies ATP1A3 variants in children with polymicrogyria and maps ATP1A3 expression patterns in human neocortex development using single-cell RNA sequencing.

The paper profiles interneurons in primates and rodents to identify evolutionary innovations in brain cell types and their molecular features.