Cancer BiologybioRxivPreprint
Loss of the Y chromosome is transcriptionally silent in clear cell renal cell carcinoma and across cancer entities
Alex Waterhölter, Rebecca Scholz, Andreas Tsouris…·Ian J. Frew
The paper investigates the transcriptional impact of loss of the Y chromosome (LOY) in clear cell renal cell carcinoma (ccRCC) and other cancers, finding minimal effects beyond gene dosage and pathway-level shifts.