Melanie Boerries

Loss of the Y chromosome is transcriptionally silent in clear cell renal cell carcinoma and across cancer entities

The paper investigates the transcriptional impact of loss of the Y chromosome (LOY) in clear cell renal cell carcinoma (ccRCC) and other cancers, finding minimal effects beyond gene dosage and pathway-level shifts.

Bivalent bispecific CD28 antibodies reinforce T-cell responsiveness and revert anergy/quiescence in patients treated with bispecific CD3 antibodies

This paper develops bispecific costimulators (BiCos) that restore T-cell function in patients treated with bispecific CD3 antibodies, reversing anergy and quiescence through enhanced signaling.

Prospective pan-cancer phosphoproteomics at clinical scale extends therapeutic options in precision oncology

This study uses pan-cancer phosphoproteomics to identify therapeutic targets and improve precision oncology by analyzing 1,998 tumor samples and developing new scores for kinase activity and immune response.

Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomas

This study identifies hypoxia-associated transcriptional plasticity in IDH-mutant gliomas, showing microglia-driven quiescent-to-activated transitions that drive malignant progression.

Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoids

This study shows that Smac mimetics induce apoptosis in breast cancer organoids and that necroptosis, associated with inflammation, can be inhibited by LUBAC inhibitors.

A physiological Na+ signal activates mitochondrial PINK1 to couple synaptic depression to caspase-3-dependent spine pruning

This study identifies a Na+-PINK1 signaling pathway that links NMDA receptor activity to mitochondrial fission and caspase-3-dependent synapse elimination during long-term depression.

Immunomodulatory impact of PTPN11/SHP2-based vertical RAS-MAPK pathway inhibition in pancreatic cancer

This study investigates the immunomodulatory effects of SHP2-based vertical RAS pathway inhibition in pancreatic cancer, revealing both immune-activating and suppressive changes that evolve with treatment.

Sexually dimorphic effects of mutations in ccRCC driver genes in renal proximal tubule cells

The paper investigates sex-specific effects of Vhl and Vhl/Pbrm1 mutations in renal proximal tubule cells, revealing differences in lipid droplet accumulation and clonal expansion between males and females.

Preimplantation factor (PIF) is an endogenous inhibitor of potassium channel KV1.3 regulating neutrophil function during pregnancy

The paper identifies PIF as a placenta-derived peptide that inhibits KV1.3 channels in neutrophils, altering their function during pregnancy.

Castling, a novel therapeutic concept for rewiring pathological gene-expression networks, enabled by the TRIPLE technology

The paper introduces a therapeutic strategy called castling to correct gene-expression imbalances by rewiring miRNA regulation using the TRIPLE genome-editing technology.

Macrophage renewal in the small intestine governs early-life control of streptococci

This study shows that small intestine macrophage dynamics control GBS colonization and invasion in infant mice, with region-specific responses to the pathogen.

Vertical RAS-pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development

This study shows the PIDDosome restricts cardiomyocyte polyploidization during postnatal heart development through p21/Cdkn1a, independent of p53.

Hematological phenotypes in GATA2 deficiency syndrome arise from secondary injuries and maladaptation to proliferation

This study shows that GATA2 deficiency leads to hematological issues through bone marrow failure and maladaptation, with leukemia arising from genomic instability and proliferation defects.

The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses

This study investigates the role of amyloid precursor protein (APP) in synaptic transmission at medial perforant path synapses using organotypic cultures and finds that presynaptic APP affects neurotransmission efficacy.

Tumor necrosis factor α modulates excitatory and inhibitory neurotransmission in a concentration-dependent manner

This study shows that TNF affects excitatory and inhibitory neurotransmission differently at low and high concentrations, with high concentrations activating microglia and inducing homeostatic effects.