Andreas Tsouris

Loss of the Y chromosome is transcriptionally silent in clear cell renal cell carcinoma and across cancer entities

The paper investigates the transcriptional impact of loss of the Y chromosome (LOY) in clear cell renal cell carcinoma (ccRCC) and other cancers, finding minimal effects beyond gene dosage and pathway-level shifts.

Castling, a novel therapeutic concept for rewiring pathological gene-expression networks, enabled by the TRIPLE technology

The paper introduces a therapeutic strategy called castling to correct gene-expression imbalances by rewiring miRNA regulation using the TRIPLE genome-editing technology.

Diallel panel reveals a significant impact of low-frequency genetic variants on gene expression variation in yeast

The paper uses a diallel panel of yeast hybrids to show low-frequency SNPs have a larger impact on gene expression than common SNPs or SVs.

Non-additive genetic components contribute significantly to population-wide gene expression variation

The paper estimates heritability of gene expression traits in yeast hybrids and finds non-additive components account for 36% of phenotypic variance.

Contrasting genomic evolution between domesticated and wild Kluyveromyces lactis yeast populations

This study compares genomic evolution between domesticated and wild Kluyveromyces lactis yeast populations, finding reduced diversity and gene introgression in domesticated strains.

nPhase: An accurate and contiguous phasing method for polyploids

nPhase is a polyploidy-agnostic phasing method that achieves high accuracy and contiguity in haplotype prediction for polyploid genomes.

High-throughput functional analysis of natural variants in yeast

The paper presents a high-throughput assay to measure the fitness of natural alleles in yeast, identifying functional and nonfunctional variants and their effects on phenotype.