Francesca Cuomo

Loss of the Y chromosome is transcriptionally silent in clear cell renal cell carcinoma and across cancer entities

The paper investigates the transcriptional impact of loss of the Y chromosome (LOY) in clear cell renal cell carcinoma (ccRCC) and other cancers, finding minimal effects beyond gene dosage and pathway-level shifts.

Sexually dimorphic effects of mutations in ccRCC driver genes in renal proximal tubule cells

The paper investigates sex-specific effects of Vhl and Vhl/Pbrm1 mutations in renal proximal tubule cells, revealing differences in lipid droplet accumulation and clonal expansion between males and females.

Assessment of community efforts to advance computational prediction of protein-protein interactions

The paper evaluates 24 network-based methods for predicting protein-protein interactions across five interactomes, identifies top-performing methods, and validates their predictions experimentally.