Author

Ian J. Frew

University of FreiburgORCID 0000-0003-2735-5509Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alex WaterhölteriD· 2 shared Anna KöttgeniD· 2 shared Francesca CuomoiD· 2 shared Melanie BoerriesiD· 2 shared Mojca Adlesic· 2 shared Pascal SchlosseriD· 2 shared Andreas TsourisiD· 1 shared Anna L. KoessingeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Alex WaterhölterORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 9, 2026

Loss of the Y chromosome is transcriptionally silent in clear cell renal cell carcinoma and across cancer entities

Alex Waterhölter, Rebecca Scholz, Andreas Tsouris…·Ian J. Frew

The paper investigates the transcriptional impact of loss of the Y chromosome (LOY) in clear cell renal cell carcinoma (ccRCC) and other cancers, finding minimal effects beyond gene dosage and pathway-level shifts.

DOI 10.64898/2026.10.08.757570

humanmouse

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 26, 2026

Sexually dimorphic effects of mutations in ccRCC driver genes in renal proximal tubule cells

Antonella Catalano, Constanze Kainz, Katharina Moos…·Mojca Adlesic

The paper investigates sex-specific effects of Vhl and Vhl/Pbrm1 mutations in renal proximal tubule cells, revealing differences in lipid droplet accumulation and clonal expansion between males and females.

DOI 10.64898/2026.05.22.727114

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologyiSciencePeer-reviewedMar 11, 2025

Versatile roles of Annexin A4 in ccRCC: impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment

Maximilian Wess, Manuel Rogg, Constance Gueib-Picard…·Christoph Schell

This study identifies ANXA4 as a key player in ccRCC, showing its role in membrane repair, transcriptional changes, and tumor microenvironment composition through genetic and computational analyses.

4 citations

humanbulk RNA-seq

𝕏 PostBluesky